› 1nfo

X-ray diffraction
2Å resolution

APOLIPOPROTEIN E2 (APOE2, D154A MUTATION)

Released:
DOI: 10.2210/pdb1nfo/pdb
PDB entry 1nfo coloured by chain, front view.
PDB entry 1nfo coloured by chain, side view.
PDB entry 1nfo coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Novel mechanism for defective receptor binding of apolipoprotein E2 in type III hyperlipoproteinemia.
Dong LM, Parkin S, Trakhanov SD, Rupp B, Simmons T, Arnold KS, Newhouse YM, Innerarity TL, Weisgraber KH
Nat Struct Biol 3 718-22 (1996)
PMID: 8756331

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-135991 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Apolipoprotein E Chain: A
Molecule details ›
Chain: A
Length: 191 amino acids
Theoretical weight: 22.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02649 (Residues: 19-209; Coverage: 64%)
Gene name: APOE
Sequence domains: Apolipoprotein A1/A4/E domain
Structure domains: Apolipoprotein

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH2R
Spacegroup: P212121
Unit cell:
a: 40.613Å b: 53.671Å c: 84.795Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.221 not available 0.27
Expression system: Escherichia coli

Quick links

Citations

23 review citations

Apolipoprotein E: far more than a lipid transport protein.
Mahley et al. (2000)
22 more

4 mentions without citation

Apolipoprotein E: Structural Insights and Links to Alzheimer Disease Pathogenesis.
Chen et al. (2021)
3 more