› 1nnp

X-ray diffraction
1.9Å resolution

X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-ATPA at 1.9 A resolution. Crystallization without zinc ions.

Released:
DOI: 10.2210/pdb1nnp/pdb
PDB entry 1nnp coloured by chain, front view.
PDB entry 1nnp coloured by chain, side view.
PDB entry 1nnp coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Three-dimensional structure of the ligand-binding core of GluR2 in complex with the agonist (S)-ATPA: implications for receptor subunit selectivity.
Lunn ML, Hogner A, Stensbøl TB, Gouaux E, Egebjerg J, Kastrup JS
J Med Chem 46 872-5 (2003)
PMID: 12593667

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148607 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 263 amino acids
Theoretical weight: 29.22 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P19491 (Residues: 413-527, 653-796; Coverage: 30%)
Gene names: GluA2, Glur2, Gria2
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

2 bound ligands:
Ligand SO4 2 x SO4
Ligand CE2 2 x CE2
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I711
Spacegroup: P21212
Unit cell:
a: 96.728Å b: 121.469Å c: 47.105Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.19 0.19 0.216
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

11 review citations

Glutamate receptor ion channels: structure, regulation, and function.
Traynelis et al. (2010)
10 more

2 mentions without citation

Size matters in activation/inhibition of ligand-gated ion channels.
Du et al. (2012)
1 more