› 1nq2

X-ray diffraction
2.4Å resolution

Two RTH Mutants with Impaired Hormone Binding

Released:
DOI: 10.2210/pdb1nq2/pdb
PDB entry 1nq2 coloured by chain, front view.
PDB entry 1nq2 coloured by chain, side view.
PDB entry 1nq2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Two resistance to thyroid hormone mutants with impaired hormone binding.
Huber BR, Sandler B, West BL, Cunha Lima ST, Nguyen HT, Apriletti JW, Baxter JD, Fletterick RJ
Mol Endocrinol 17 643-52 (2003)
PMID: 12554782

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-145480 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thyroid hormone receptor beta Chain: A
Molecule details ›
Chain: A
Length: 264 amino acids
Theoretical weight: 29.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P10828 (Residues: 202-461; Coverage: 56%)
Gene names: ERBA2, NR1A2, THR1, THRB
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

3 bound ligands:
Ligand NA 1 x NA
Ligand 4HY 1 x 4HY
Ligand ARS 5 x ARS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: P3121
Unit cell:
a: 68.954Å b: 68.954Å c: 131.4Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.227 0.227 0.264
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Conformational adaptation of nuclear receptor ligand binding domains to agonists: potential for novel approaches to ligand design.
Togashi et al. (2005)
9 other articles

3 mentions without citation

Halogen bonds in biological molecules.
Auffinger et al. (2004)
2 more