› 1nq9

X-ray diffraction
2.6Å resolution

Crystal Structure of Antithrombin in the Pentasaccharide-Bound Intermediate State

Released:
DOI: 10.2210/pdb1nq9/pdb
PDB entry 1nq9 coloured by chain, front view.
PDB entry 1nq9 coloured by chain, side view.
PDB entry 1nq9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of antithrombin in a heparin-bound intermediate state.
Johnson DJ, Huntington JA
Biochemistry 42 8712-9 (2003)
PMID: 12873131

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133776 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Antithrombin-III Chains: I, L
Molecule details ›
Chains: I, L
Length: 432 amino acids
Theoretical weight: 49.1 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01008 (Residues: 33-464; Coverage: 100%)
Gene names: AT3, PRO0309, SERPINC1
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: Z9L, Z9K, GU6, GU1, Z9H
Carbohydrate polymer
1 bound ligand:
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX14.1
Spacegroup: P21
Unit cell:
a: 69.679Å b: 86.76Å c: 96.921Å
α: 90° β: 109.54° γ: 90°
R-values:
R R work R free
0.209 0.209 0.25

Quick links

Citations

7 review citations

Heparan sulfate and heparin interactions with proteins.
Meneghetti et al. (2015)
6 more

7 mentions without citation

Molecular mechanisms of antithrombin-heparin regulation of blood clotting proteinases. A paradigm for understanding proteinase regulation by serpin family protein proteinase inhibitors.
Olson et al. (2010)
6 more