› 1nr4

X-ray diffraction
1.72Å resolution

High resolution crystal structures of thymus and activation-regulated chemokine

Released:
DOI: 10.2210/pdb1nr4/pdb
PDB entry 1nr4 coloured by chain, front view.
PDB entry 1nr4 coloured by chain, side view.
PDB entry 1nr4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of thymus and activation-regulated chemokine (TARC).
Asojo OA, Boulègue C, Hoover DM, Lu W, Lubkowski J
Acta Crystallogr D Biol Crystallogr 59 1165-73 (2003)
PMID: 12832759

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo octamer
Assembly name:
PDBe Complex ID:
PDB-CPX-187700 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
C-C motif chemokine 17 Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 71 amino acids
Theoretical weight: 8.1 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q92583 (Residues: 24-94; Coverage: 100%)
Gene names: CCL17, SCYA17, TARC
Sequence domains: Small cytokines (intecrine/chemokine), interleukin-8 like
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)

Ligands and Environments

1 bound ligand:
Ligand SO4 6 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P1
Unit cell:
a: 44.35Å b: 56.525Å c: 76.616Å
α: 69.97° β: 85.56° γ: 72.74°
R-values:
R R work R free
0.238 0.199 0.239
Expression system: Not provided

Quick links

Citations

1 review citation

Chemokine oligomerization in cell signaling and migration.
Wang et al. (2013)
7 other articles

10 mentions without citation

The marriage of chemokines and galectins as functional heterodimers.
von Hundelshausen et al. (2021)
9 more