› 1ntl

X-ray solution scattering
30Å resolution

Model of mouse Crry-Ig determined by solution scattering, curve fitting and homology modelling

Released:
DOI: 10.2210/pdb1ntl/pdb
PDB entry 1ntl coloured by chain, ensemble of 2 models, front view.
PDB entry 1ntl coloured by chain, ensemble of 2 models, side view.
PDB entry 1ntl coloured by chain, ensemble of 2 models, top view.
Source organism: Mus musculus
Primary publication:
The extended multidomain solution structures of the complement protein Crry and its chimeric conjugate Crry-Ig by scattering, analytical ultracentrifugation and constrained modelling: implications for function and therapy.
Aslam M, Guthridge JM, Hack BK, Quigg RJ, Holers VM, Perkins SJ
J Mol Biol 329 525-50 (2003)
PMID: 12767833

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134947 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ig gamma-1 chain C region secreted form Chains: A, B
Molecule details ›
Chains: A, B
Length: 551 amino acids
Theoretical weight: 61.82 KDa
Source organism: Mus musculus
Expression system: Mus musculus
UniProt:
  • Canonical: P01868 (Residues: 98-324; Coverage: 70%)
Gene names: Igh-4, Ighg1
Sequence domains: Immunoglobulin C1-set domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

R-values:
R R work R free 0.096 not available not available
Expression system: Mus musculus

Quick links

Citations

2 review citations

X-ray solution scattering (SAXS) combined with crystallography and computation: defining accurate macromolecular structures, conformations and assemblies in solution.
Putnam et al. (2007)
1 more

1 mention without citation

An allelic variant of Crry in the murine Sle1c lupus susceptibility interval is not impaired in its ability to regulate complement activation.
Tchepeleva et al. (2010)