› 1nue

X-ray diffraction
2Å resolution

X-RAY STRUCTURE OF NM23 HUMAN NUCLEOSIDE DIPHOSPHATE KINASE B COMPLEXED WITH GDP AT 2 ANGSTROMS RESOLUTION

Released:
DOI: 10.2210/pdb1nue/pdb
PDB entry 1nue coloured by chain, front view.
PDB entry 1nue coloured by chain, side view.
PDB entry 1nue coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
X-ray structure of human nucleoside diphosphate kinase B complexed with GDP at 2 A resolution.
Moréra S, Lacombe ML, Xu Y, LeBras G, Janin J
Structure 3 1307-14 (1995)
PMID: 8747457

Function and Biology Details

Reactions catalysed: 
ATP + protein L-histidine = ADP + protein N-phospho-L-histidine
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149622 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nucleoside diphosphate kinase B Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 151 amino acids
Theoretical weight: 17.19 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P22392 (Residues: 2-152; Coverage: 99%)
Gene names: NM23B, NME2
Sequence domains: Nucleoside diphosphate kinase
Structure domains: Nucleoside diphosphate kinase-like domain

Ligands and Environments

2 bound ligands:
Ligand MG 2 x MG
Ligand GDP 6 x GDP
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 70.03Å b: 87.37Å c: 162.1Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.177 0.177 not available

Quick links

Citations

18 review citations

The human Nm23/nucleoside diphosphate kinases.
Lacombe et al. (2000)
17 more

15 mentions without citation

NME/NM23/NDPK and Histidine Phosphorylation.
Adam et al. (2020)
14 more