› 1nyp

Solution NMR

4th LIM domain of PINCH protein

Released:
DOI: 10.2210/pdb1nyp/pdb
PDB entry 1nyp coloured by chain, ensemble of 20 models, front view.
PDB entry 1nyp coloured by chain, ensemble of 20 models, side view.
PDB entry 1nyp coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural and functional insights into PINCH LIM4 domain-mediated integrin signaling.
Velyvis A, Vaynberg J, Yang Y, Vinogradova O, Zhang Y, Wu C, Qin J
Nat Struct Biol 10 558-64 (2003)
PMID: 12794636

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155699 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
LIM and senescent cell antigen-like-containing domain protein 1 Chain: A
Molecule details ›
Chain: A
Length: 66 amino acids
Theoretical weight: 7.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P48059 (Residues: 188-251; Coverage: 20%)
Gene names: LIMS1, PINCH, PINCH1
Sequence domains: LIM domain
Structure domains: Cysteine Rich Protein

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

15 review citations

The LIM domain: from the cytoskeleton to the nucleus.
Kadrmas et al. (2004)
14 more

5 mentions without citation

ILK: a pseudokinase in the center stage of cell-matrix adhesion and signaling.
Qin et al. (2012)
4 more