› 1o0k

X-ray diffraction
1.17Å resolution

Structure of the First Parallel DNA Quadruplex-drug Complex

Released:
DOI: 10.2210/pdb1o0k/pdb
PDB entry 1o0k coloured by chain, front view.
PDB entry 1o0k coloured by chain, side view.
PDB entry 1o0k coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Structure of the first parallel DNA quadruplex-drug complex.
Clark GR, Pytel PD, Squire CJ, Neidle S
J Am Chem Soc 125 4066-7 (2003)
PMID: 12670225

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-114291 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
5'-D(*TP*GP*GP*GP*GP*T)-3' Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 6 nucleotides
Theoretical weight: 1.88 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand NA 3 x NA
Ligand DM1 3 x DM1
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL
Spacegroup: C2
Unit cell:
a: 53.004Å b: 47.073Å c: 31.865Å
α: 90° β: 119.8° γ: 90°
Expression system: Not provided

Quick links

Citations

17 review citations

A hitchhiker's guide to G-quadruplex ligands.
Monchaud et al. (2008)
16 more

9 mentions without citation

Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics.
Patel et al. (2007)
8 more