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Heterodimer of p40phox and p67phox PB1 domains from human NADPH oxidase

X-ray diffraction
2Å resolution
PDB entry 1oey coloured by chain, front view.
PDB entry 1oey coloured by chain, side view.
PDB entry 1oey coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Neutrophil cytosol factor 4 and Neutrophil cytosol factor 2
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Multimeric state: hetero dimer
Accessible surface area: 11812.23 Å2
Buried surface area: 1377.45 Å2
Dissociation area: 688.72 Å2
Dissociation energy (ΔGdiss): -2.45 kcal/mol
Dissociation entropy (TΔSdiss): 10.65 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-148780
Assembly 2
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Assembly Name: Neutrophil cytosol factor 4 and Neutrophil cytosol factor 2
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Multimeric state: hetero dimer
Accessible surface area: 10989.2 Å2
Buried surface area: 1366.59 Å2
Dissociation area: 683.3 Å2
Dissociation energy (ΔGdiss): -2.49 kcal/mol
Dissociation entropy (TΔSdiss): 10.52 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-148780
Assembly 3
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Assembly Name: Neutrophil cytosol factor 4 and Neutrophil cytosol factor 2
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Multimeric state: hetero dimer
Accessible surface area: 10713.54 Å2
Buried surface area: 1364.99 Å2
Dissociation area: 682.49 Å2
Dissociation energy (ΔGdiss): -3.29 kcal/mol
Dissociation entropy (TΔSdiss): 10.49 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-148780
Assembly 4
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Assembly Name: Neutrophil cytosol factor 4 and Neutrophil cytosol factor 2
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Multimeric state: hetero dimer
Accessible surface area: 10775.98 Å2
Buried surface area: 1405.15 Å2
Dissociation area: 702.57 Å2
Dissociation energy (ΔGdiss): -3.97 kcal/mol
Dissociation entropy (TΔSdiss): 10.53 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-148780

Macromolecules

Neutrophil cytosol factor 2
Chains: A, B, C, D
Length: 83 amino acids
Theoretical weight: 9.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P19878 (Residues: 350-429; Coverage: 15%)
Gene names: NCF2, NOXA2, P67PHOX
Pfam: PB1 domain
InterPro:
CATH: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
SCOP: PB1 domain
Neutrophil cytosol factor 2 in PDB entry 1oey, assembly 1, front view.
Neutrophil cytosol factor 2 in PDB entry 1oey, assembly 1, side view.
Neutrophil cytosol factor 2 in PDB entry 1oey, assembly 1, top view.
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Neutrophil cytosol factor 4
Chains: J, K, L, M
Length: 107 amino acids
Theoretical weight: 12.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q15080 (Residues: 237-339; Coverage: 30%)
Gene names: NCF4, SH3PXD4
Pfam: PB1 domain
InterPro:
CATH: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
SCOP: PB1 domain
Neutrophil cytosol factor 4 in PDB entry 1oey, assembly 1, front view.
Neutrophil cytosol factor 4 in PDB entry 1oey, assembly 1, side view.
Neutrophil cytosol factor 4 in PDB entry 1oey, assembly 1, top view.
Molecule details ›

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