› 1ojy

X-ray diffraction
2.6Å resolution

Decay accelerating factor (cd55): the structure of an intact human complement regulator.

Released:
DOI: 10.2210/pdb1ojy/pdb
PDB entry 1ojy coloured by chain, front view.
PDB entry 1ojy coloured by chain, side view.
PDB entry 1ojy coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Complement regulation at the molecular level: the structure of decay-accelerating factor.
Lukacik P, Roversi P, White J, Esser D, Smith GP, Billington J, Williams PA, Rudd PM, Wormald MR, Harvey DJ, Crispin MD, Radcliffe CM, Dwek RA, Evans DJ, Morgan BP, Smith RA, Lea SM
Proc Natl Acad Sci U S A 101 1279-84 (2004)
PMID: 14734808

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139970 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Complement decay-accelerating factor Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 254 amino acids
Theoretical weight: 28.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P08174 (Residues: 35-285; Coverage: 72%)
Gene names: CD55, CR, DAF
Sequence domains: Sushi repeat (SCR repeat)
Structure domains: Complement Module, domain 1

Ligands and Environments

3 bound ligands:
Ligand ACT 4 x ACT
Ligand GOL 6 x GOL
Ligand SO4 3 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P1
Unit cell:
a: 51.829Å b: 78.694Å c: 80.903Å
α: 72.7° β: 79.38° γ: 81.7°
R-values:
R R work R free
0.254 not available not available
Expression system: Escherichia coli

Quick links

Citations

16 review citations

Complement evasion by human pathogens.
Lambris et al. (2008)
15 more

5 mentions without citation

Complement regulation at the molecular level: the structure of decay-accelerating factor.
Lukacik et al. (2004)
4 more