› 1oog

X-ray diffraction
1.45Å resolution

Complex of Drosophila odorant binding protein LUSH with propanol

Released:
DOI: 10.2210/pdb1oog/pdb
PDB entry 1oog coloured by chain, front view.
PDB entry 1oog coloured by chain, side view.
PDB entry 1oog coloured by chain, top view.
Source organism: Drosophila melanogaster
Primary publication:
Structure of a specific alcohol-binding site defined by the odorant binding protein LUSH from Drosophila melanogaster.
Kruse SW, Zhao R, Smith DP, Jones DN
Nat Struct Biol 10 694-700 (2003)
PMID: 12881720

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126416 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
General odorant-binding protein lush Chains: A, B
Molecule details ›
Chains: A, B
Length: 124 amino acids
Theoretical weight: 14.22 KDa
Source organism: Drosophila melanogaster
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O02372 (Residues: 30-153; Coverage: 100%)
Gene names: CG8807, Obp76a, Obp76c, lush
Sequence domains: PBP/GOBP family
Structure domains: Pheromone/general odorant binding protein domain

Ligands and Environments

2 bound ligands:
Ligand ACT 4 x ACT
Ligand POL 2 x POL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: P43
Unit cell:
a: 46.98Å b: 46.98Å c: 111.457Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.176 0.174 0.197
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

22 review citations

Alcoholism: a systems approach from molecular physiology to addictive behavior.
Spanagel R. (2009)
21 more

2 mentions without citation

Structure of a specific alcohol-binding site defined by the odorant binding protein LUSH from Drosophila melanogaster.
Kruse et al. (2003)
1 more