› 1opk

X-ray diffraction
1.8Å resolution

Structural basis for the auto-inhibition of c-Abl tyrosine kinase

Released:
DOI: 10.2210/pdb1opk/pdb
PDB entry 1opk coloured by chain, front view.
PDB entry 1opk coloured by chain, side view.
PDB entry 1opk coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural basis for the autoinhibition of c-Abl tyrosine kinase.
Nagar B, Hantschel O, Young MA, Scheffzek K, Veach D, Bornmann W, Clarkson B, Superti-Furga G, Kuriyan J
Cell 112 859-71 (2003)
PMID: 12654251

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132624 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase ABL1 Chain: A
Molecule details ›
Chain: A
Length: 495 amino acids
Theoretical weight: 56.19 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P00520 (Residues: 27-515; Coverage: 44%)
Gene names: Abl, Abl1
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand MYR 1 x MYR
Ligand P16 1 x P16
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: C2221
Unit cell:
a: 118.328Å b: 123.943Å c: 74.798Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.196 0.196 0.221
Expression system: Spodoptera frugiperda

Quick links

Citations

113 review citations

Targeting cancer with small molecule kinase inhibitors.
Zhang et al. (2009)
112 more

48 mentions without citation

Catalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms.
Jura et al. (2011)
47 more