› 1ow1

X-ray diffraction
1.8Å resolution

Crystal structure of the SPOC domain of the human transcriptional corepressor, SHARP.

Released:
DOI: 10.2210/pdb1ow1/pdb
PDB entry 1ow1 coloured by chain, front view.
PDB entry 1ow1 coloured by chain, side view.
PDB entry 1ow1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A conserved structural motif reveals the essential transcriptional repression function of Spen proteins and their role in developmental signaling.
Ariyoshi M, Schwabe JW
Genes Dev 17 1909-20 (2003)
PMID: 12897056

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188762 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Msx2-interacting protein Chain: A
Molecule details ›
Chain: A
Length: 195 amino acids
Theoretical weight: 21.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96T58 (Residues: 3470-3664; Coverage: 5%)
Gene names: KIAA0929, MINT, SHARP, SPEN
Sequence domains: SPOC domain
Structure domains: Ku70; Chain: A; Domain 2

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX14.2
Spacegroup: P212121
Unit cell:
a: 41.3Å b: 61.98Å c: 68.4Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.214 0.214 0.249
Expression system: Escherichia coli

Quick links

Citations

20 review citations

The Varied Roles of Notch in Cancer.
Aster et al. (2017)
19 more

10 mentions without citation

Nuclear hormone receptor co-repressors: structure and function.
Watson et al. (2012)
9 more