Function and Biology Details
Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:
Structure analysis Details
Assembly composition:
hetero pentamer (preferred)
Assembly name:
Paxillin and Focal adhesion kinase 1 (preferred)
PDBe Complex ID:
PDB-CPX-155839 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Focal adhesion kinase 1
Molecule details ›
Chains: A, B, C
Length: 161 amino acids
Theoretical weight: 17.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: Focal adhesion targeting region
Structure domains:
Length: 161 amino acids
Theoretical weight: 17.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
Q05397 (Residues: 892-1052; Coverage: 15%)
Sequence domains: Focal adhesion targeting region
Structure domains:
Paxillin
Molecule details ›
Chains: D, F
Length: 13 amino acids
Theoretical weight: 1.54 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
Length: 13 amino acids
Theoretical weight: 1.54 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
- Canonical: P49023 (Residues: 141-153; Coverage: 2%)
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
ESRF BEAMLINE BM30A
Spacegroup:
C2221
Expression systems:
- Escherichia coli BL21(DE3)
- Not provided
