› 1owt

Solution NMR

Structure of the Alzheimer's disease amyloid precursor protein copper binding domain

Released:
DOI: 10.2210/pdb1owt/pdb
PDB entry 1owt coloured by chain, ensemble of 21 models, front view.
PDB entry 1owt coloured by chain, ensemble of 21 models, side view.
PDB entry 1owt coloured by chain, ensemble of 21 models, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis.
Barnham KJ, McKinstry WJ, Multhaup G, Galatis D, Morton CJ, Curtain CC, Williamson NA, White AR, Hinds MG, Norton RS, Beyreuther K, Masters CL, Parker MW, Cappai R
J Biol Chem 278 17401-7 (2003)
PMID: 12611883

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138353 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
N-APP Chain: A
Molecule details ›
Chain: A
Length: 66 amino acids
Theoretical weight: 7.59 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P05067 (Residues: 124-189; Coverage: 9%)
Gene names: A4, AD1, APP
Sequence domains: Copper-binding of amyloid precursor, CuBD
Structure domains: Amyloidogenic glycoprotein, copper-binding domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry and simulated annealing
Expression system: Komagataella pastoris

Quick links

Citations

63 review citations

Neurodegenerative diseases and oxidative stress.
Barnham et al. (2004)
62 more

10 mentions without citation

The amyloid-beta precursor protein: integrating structure with biological function.
Reinhard et al. (2005)
9 more