› 1ozs

Solution NMR

C-domain of human cardiac troponin C in complex with the inhibitory region of human cardiac troponin I

Released:
DOI: 10.2210/pdb1ozs/pdb
PDB entry 1ozs coloured by chain, ensemble of 30 models, front view.
PDB entry 1ozs coloured by chain, ensemble of 30 models, side view.
PDB entry 1ozs coloured by chain, ensemble of 30 models, top view.
Source organism: Homo sapiens
Primary publication:
Structure and dynamics of the C-domain of human cardiac troponin C in complex with the inhibitory region of human cardiac troponin I.
Lindhout DA, Sykes BD
J Biol Chem 278 27024-34 (2003)
PMID: 12732641

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148574 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Troponin C, slow skeletal and cardiac muscles Chain: A
Molecule details ›
Chain: A
Length: 73 amino acids
Theoretical weight: 8.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P63316 (Residues: 90-161; Coverage: 45%)
Gene names: TNNC, TNNC1
Sequence domains: EF-hand domain pair
Structure domains: EF-hand
Troponin I, cardiac muscle Chain: B
Molecule details ›
Chain: B
Length: 20 amino acids
Theoretical weight: 2.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P19429 (Residues: 129-148; Coverage: 10%)
Gene names: TNNC1, TNNI3

Ligands and Environments

1 bound ligand:
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: 100 structures calculated using CNS simulated annealing protocol starting from extended structures
Expression system: Escherichia coli

Quick links

Citations

11 review citations

Calcium, thin filaments, and the integrative biology of cardiac contractility.
Kobayashi et al. (2005)
10 more

4 mentions without citation

Structure and function of cardiac troponin C (TNNC1): Implications for heart failure, cardiomyopathies, and troponin modulating drugs.
Li et al. (2015)
3 more