› 1p53

X-ray diffraction
3.06Å resolution

The Crystal Structure of ICAM-1 D3-D5 fragment

Released:
DOI: 10.2210/pdb1p53/pdb
PDB entry 1p53 coloured by chain, front view.
PDB entry 1p53 coloured by chain, side view.
PDB entry 1p53 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for dimerization of ICAM-1 on the cell surface.
Yang Y, Jun CD, Liu JH, Zhang R, Joachimiak A, Springer TA, Wang JH
Mol Cell 14 269-76 (2004)
PMID: 15099525

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138632 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Intercellular adhesion molecule 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 266 amino acids
Theoretical weight: 28.83 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P05362 (Residues: 212-477; Coverage: 53%)
Gene name: ICAM1
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand NAG 6 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: R32
Unit cell:
a: 193.7Å b: 193.7Å c: 175.3Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.22 0.22 0.252
Expression system: Cricetulus griseus

Quick links

Citations

16 review citations

ICAM-1 signaling in endothelial cells.
Lawson et al. (2009)
15 more

19 mentions without citation

Structural basis of integrin regulation and signaling.
Luo et al. (2007)
18 more