› 1p5t

X-ray diffraction
2.35Å resolution

Crystal Structure of Dok1 PTB Domain

Released:
DOI: 10.2210/pdb1p5t/pdb
PDB entry 1p5t coloured by chain, front view.
PDB entry 1p5t coloured by chain, side view.
PDB entry 1p5t coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural basis for the specific recognition of RET by the Dok1 phosphotyrosine binding domain.
Shi N, Ye S, Bartlam M, Yang M, Wu J, Liu Y, Sun F, Han X, Peng X, Qiang B, Yuan J, Rao Z
J Biol Chem 279 4962-9 (2004)
PMID: 14607833

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161305 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Docking protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 127 amino acids
Theoretical weight: 14.47 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P97465 (Residues: 152-266; Coverage: 24%)
Gene names: Dok, Dok1
Sequence domains: PTB domain (IRS-1 type)
Structure domains: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 4 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: P212121
Unit cell:
a: 41.11Å b: 56.25Å c: 99.79Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.223 0.218 0.265
Expression system: Escherichia coli BL21

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Citations

6 review citations

Nuclear structure in cancer cells.
Zink et al. (2004)
5 more

1 mention without citation

Predicting protein ligand binding sites by combining evolutionary sequence conservation and 3D structure.
Capra et al. (2009)