› 1p8x

X-ray diffraction
2Å resolution

The Calcium-Activated C-terminal half of gelsolin

Released:
DOI: 10.2210/pdb1p8x/pdb
PDB entry 1p8x coloured by chain, front view.
PDB entry 1p8x coloured by chain, side view.
PDB entry 1p8x coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Activation in isolation: exposure of the actin-binding site in the C-terminal half of gelsolin does not require actin.
Narayan K, Chumnarnsilpa S, Choe H, Irobi E, Urosev D, Lindberg U, Schutt CE, Burtnick LD, Robinson RC
FEBS Lett 552 82-5 (2003)
PMID: 14527664

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139010 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Gelsolin Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 344 amino acids
Theoretical weight: 37.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P06396 (Residues: 439-782; Coverage: 46%)
Gene name: GSN
Sequence domains: Gelsolin repeat
Structure domains: Severin

Ligands and Environments

1 bound ligand:
Ligand CA 9 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P212121
Unit cell:
a: 84.75Å b: 90.11Å c: 156.94Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.205 0.205 0.245
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Gelsolin: the tail of a molecular gymnast.
Nag et al. (2013)
1 more

4 mentions without citation

The crystal structure of the C-terminus of adseverin reveals the actin-binding interface.
Chumnarnsilpa et al. (2009)
3 more