› 1pa3

X-ray diffraction
2.7Å resolution

Crystal Structure of Glutathione-S-transferase from Plasmodium falciparum

Released:
DOI: 10.2210/pdb1pa3/pdb
PDB entry 1pa3 coloured by chain, front view.
PDB entry 1pa3 coloured by chain, side view.
PDB entry 1pa3 coloured by chain, top view.
Source organism: Plasmodium falciparum
Primary publication:
Native and inhibited structure of a Mu class-related glutathione S-transferase from Plasmodium falciparum.
Perbandt M, Burmeister C, Walter RD, Betzel C, Liebau E
J Biol Chem 279 1336-42 (2004)
PMID: 12972411

Function and Biology Details

Reaction catalysed: 
RX + glutathione = HX + R-S-glutathione
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-184818 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutathione S-transferase Chains: A, B
Molecule details ›
Chains: A, B
Length: 211 amino acids
Theoretical weight: 24.82 KDa
Source organism: Plasmodium falciparum
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8ILQ7 (Residues: 1-211; Coverage: 100%)
Gene names: GST, PF14_0187, PF3D7_1419300
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P21212
Unit cell:
a: 62.1Å b: 88.2Å c: 75.4Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.23 0.228 0.285
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Redox and antioxidant systems of the malaria parasite Plasmodium falciparum.
Müller S. (2004)
3 more

2 mentions without citation

The Potential of Secondary Metabolites from Plants as Drugs or Leads against Protozoan Neglected Diseases-Part III: In-Silico Molecular Docking Investigations.
Ogungbe et al. (2016)
1 more