› 1pb8

X-ray diffraction
1.45Å resolution

CRYSTAL STRUCTURE OF THE NR1 LIGAND BINDING CORE IN COMPLEX WITH D-SERINE AT 1.45 ANGSTROMS RESOLUTION

Released:
DOI: 10.2210/pdb1pb8/pdb
PDB entry 1pb8 coloured by chain, front view.
PDB entry 1pb8 coloured by chain, side view.
PDB entry 1pb8 coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core.
Furukawa H, Gouaux E
EMBO J 22 2873-85 (2003)
PMID: 12805203

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152906 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor ionotropic, NMDA 1 Chain: A
Molecule details ›
Chain: A
Length: 292 amino acids
Theoretical weight: 33.33 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P35439 (Residues: 394-800; Coverage: 32%)
Gene names: Grin1, Nmdar1
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

1 bound ligand:
Ligand DSN 1 x DSN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P212121
Unit cell:
a: 41.46Å b: 73.06Å c: 96.89Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.204 0.204 0.226
Expression system: Escherichia coli

Quick links

Citations

75 review citations

Glutamate receptor ion channels: structure, regulation, and function.
Traynelis et al. (2010)
74 more

12 mentions without citation

Human Serine Racemase: Key Residues/Active Site Motifs and Their Relation to Enzyme Function.
Graham et al. (2019)
11 more