› 1pdu

X-ray diffraction
2.3Å resolution

Ligand-binding domain of Drosophila orphan nuclear receptor DHR38

Released:
DOI: 10.2210/pdb1pdu/pdb
PDB entry 1pdu coloured by chain, front view.
PDB entry 1pdu coloured by chain, side view.
PDB entry 1pdu coloured by chain, top view.
Source organism: Drosophila melanogaster
Primary publication:
The Drosophila orphan nuclear receptor DHR38 mediates an atypical ecdysteroid signaling pathway.
Baker KD, Shewchuk LM, Kozlova T, Makishima M, Hassell A, Wisely B, Caravella JA, Lambert MH, Reinking JL, Krause H, Thummel CS, Willson TM, Mangelsdorf DJ
Cell 113 731-42 (2003)
PMID: 12809604

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156070 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Probable nuclear hormone receptor HR38 Chains: A, B
Molecule details ›
Chains: A, B
Length: 244 amino acids
Theoretical weight: 28.18 KDa
Source organism: Drosophila melanogaster
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P49869 (Residues: 842-1073; Coverage: 22%)
Gene names: CG1864, Hr38, NR4A4
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P212121
Unit cell:
a: 78.379Å b: 82.231Å c: 84.147Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.21 0.27
Expression system: Escherichia coli BL21

Quick links

Citations

36 review citations

Nuclear receptors--a perspective from Drosophila.
King-Jones et al. (2005)
35 more