› 1phr

X-ray diffraction
2.1Å resolution

THE CRYSTAL STRUCTURE OF A LOW MOLECULAR PHOSPHOTYROSINE PROTEIN PHOSPHATASE

Released:
DOI: 10.2210/pdb1phr/pdb
PDB entry 1phr coloured by chain, front view.
PDB entry 1phr coloured by chain, side view.
PDB entry 1phr coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
The crystal structure of a low-molecular-weight phosphotyrosine protein phosphatase.
Su XD, Taddei N, Stefani M, Ramponi G, Nordlund P
Nature 370 575-8 (1994)
PMID: 8052313

Function and Biology Details

Reactions catalysed: 
A phosphate monoester + H(2)O = an alcohol + phosphate
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145642 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Low molecular weight phosphotyrosine protein phosphatase Chain: A
Molecule details ›
Chain: A
Length: 157 amino acids
Theoretical weight: 17.95 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P11064 (Residues: 2-158; Coverage: 99%)
Gene name: ACP1
Sequence domains: Low molecular weight phosphotyrosine protein phosphatase
Structure domains: Rossmann fold

Ligands and Environments

1 bound ligand:
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 46.3Å b: 62.2Å c: 62.7Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.167 0.167 0.232

Quick links

Citations

23 review citations

Protein tyrosine phosphatases in the human genome.
Alonso et al. (2004)
22 more

5 mentions without citation

Overview of protein structural and functional folds.
Sun et al. (2004)
4 more