Function and Biology Details
Reaction catalysed:
L-phenylalanine + tetrahydrobiopterin + O(2) = L-tyrosine + 4a-hydroxytetrahydrobiopterin
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence domains:
- Aromatic amino acid hydroxylase, C-terminal
- ACT domain
- Aromatic amino acid hydroxylase, iron/copper binding site
- Eukaryotic phenylalanine-4-hydroxylase, catalytic domain
- Aromatic amino acid monoxygenase, C-terminal domain superfamily
- ACT-like domain
- Aromatic amino acid hydroxylase
- Phenylalanine-4-hydroxylase, tetrameric form
2 more domains
Structure analysis Details
Assembly composition:
homo dimer (preferred)
Assembly name:
Phenylalanine-4-hydroxylase (preferred)
PDBe Complex ID:
PDB-CPX-137480 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phenylalanine-4-hydroxylase
Molecule details ›
Chain: A
Length: 429 amino acids
Theoretical weight: 49.33 KDa
Source organism: Rattus norvegicus
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains:
Structure domains: Aromatic amino acid hydroxylase
Length: 429 amino acids
Theoretical weight: 49.33 KDa
Source organism: Rattus norvegicus
Expression system: Spodoptera frugiperda
UniProt:
- Canonical:
P04176 (Residues: 1-429; Coverage: 95%)
Sequence domains:
Structure domains: Aromatic amino acid hydroxylase
