› 1pn5

Solution NMR

NMR structure of the NALP1 Pyrin domain (PYD)

Released:
DOI: 10.2210/pdb1pn5/pdb
PDB entry 1pn5 coloured by chain, ensemble of 20 models, front view.
PDB entry 1pn5 coloured by chain, ensemble of 20 models, side view.
PDB entry 1pn5 coloured by chain, ensemble of 20 models, top view.
Source organisms:
Primary publication:
NMR structure of the apoptosis- and inflammation-related NALP1 pyrin domain.
Hiller S, Kohl A, Fiorito F, Herrmann T, Wider G, Tschopp J, Grütter MG, Wüthrich K
Structure 11 1199-205 (2003)
PMID: 14527388

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139121 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Immunoglobulin G-binding protein G; NACHT, LRR and PYD domains-containing protein 1, N-terminus Chain: A
Molecule details ›
Chain: A
Length: 159 amino acids
Theoretical weight: 17.68 KDa
Source organisms: Expression system: Escherichia coli
UniProt:
  • Canonical: P06654 (Residues: 228-282; Coverage: 13%)
  • Canonical: Q9C000 (Residues: 1-93; Coverage: 6%)
Gene names: CARD7, DEFCAP, KIAA0926, NAC, NALP1, NLRP1, spg
Sequence domains:
Structure domains: Death Domain, Fas

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

28 review citations

Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases.
Martinon et al. (2004)
27 more

22 mentions without citation

International Union of Basic and Clinical Pharmacology. XCVI. Pattern recognition receptors in health and disease.
Bryant et al. (2015)
21 more