› 1pnt

X-ray diffraction
2.2Å resolution

CRYSTAL STRUCTURE OF BOVINE HEART PHOSPHOTYROSYL PHOSPHATASE AT 2.2 ANGSTROMS RESOLUTION

Released:
DOI: 10.2210/pdb1pnt/pdb
PDB entry 1pnt coloured by chain, front view.
PDB entry 1pnt coloured by chain, side view.
PDB entry 1pnt coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Crystal structure of bovine heart phosphotyrosyl phosphatase at 2.2-A resolution.
Zhang M, Van Etten RL, Stauffacher CV
Biochemistry 33 11097-105 (1994)
PMID: 7537084

Function and Biology Details

Reactions catalysed: 
A phosphate monoester + H(2)O = an alcohol + phosphate
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145642 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Low molecular weight phosphotyrosine protein phosphatase Chain: A
Molecule details ›
Chain: A
Length: 157 amino acids
Theoretical weight: 17.95 KDa
Source organism: Bos taurus
Expression system: Not provided
UniProt:
  • Canonical: P11064 (Residues: 2-158; Coverage: 99%)
Gene name: ACP1
Sequence domains: Low molecular weight phosphotyrosine protein phosphatase
Structure domains: Rossmann fold

Ligands and Environments

1 bound ligand:
Ligand PO4 1 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: C2
Unit cell:
a: 95.3Å b: 43.3Å c: 41.2Å
α: 90° β: 113.5° γ: 90°
R-values:
R R work R free
0.166 0.166 not available
Expression system: Not provided

Quick links

Citations

16 review citations

Protein tyrosine phosphatases: mechanisms of catalysis and regulation.
Denu et al. (1998)
15 more

7 mentions without citation

PKAD: a database of experimentally measured pKa values of ionizable groups in proteins.
Pahari et al. (2019)
6 more