› 1pu4

X-ray diffraction
3.2Å resolution

Crystal structure of human vascular adhesion protein-1

Released:
DOI: 10.2210/pdb1pu4/pdb
PDB entry 1pu4 coloured by chain, front view.
PDB entry 1pu4 coloured by chain, side view.
PDB entry 1pu4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the human vascular adhesion protein-1: unique structural features with functional implications.
Airenne TT, Nymalm Y, Kidron H, Smith DJ, Pihlavisto M, Salmi M, Jalkanen S, Johnson MS, Salminen TA
Protein Sci 14 1964-74 (2005)
PMID: 16046623

Function and Biology Details

Reaction catalysed: 
RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172603 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Amine oxidase [copper-containing] 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 763 amino acids
Theoretical weight: 84.73 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: Q16853 (Residues: 1-763; Coverage: 100%)
Gene names: AOC3, VAP1
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
3 bound ligands:
Ligand NAG 2 x NAG
Ligand CU 2 x CU
Ligand CA 4 x CA
1 modified residue:
Ligand TPQ 2 x TPQ

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X11
Spacegroup: P6522
Unit cell:
a: 225.916Å b: 225.916Å c: 218.668Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.219 0.217 0.254
Expression system: Cricetulus griseus

Quick links

Citations

12 review citations

Cell-surface enzymes in control of leukocyte trafficking.
Salmi et al. (2005)
11 more

3 mentions without citation

Copper active sites in biology.
Solomon et al. (2014)
2 more