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› 1pv9

X-ray diffraction
2Å resolution

Prolidase from Pyrococcus furiosus

Released:
DOI: 10.2210/pdb1pv9/pdb
Model geometry
Fit model/data
PDB entry 1pv9 coloured by chain, front view.
PDB entry 1pv9 coloured by chain, side view.
PDB entry 1pv9 coloured by chain, top view.
Source organism: Pyrococcus furiosus
Primary publication:
Structure of the prolidase from Pyrococcus furiosus.
Maher MJ, Ghosh M, Grunden AM, Menon AL, Adams MW, Freeman HC, Guss JM
Biochemistry 43 2771-83 (2004)
PMID: 15005612

Function and Biology Details

Reaction catalysed: 
Xaa-L-Pro dipeptide + H2O = an L-alpha-amino acid + L-proline.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160535 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Xaa-Pro dipeptidase Chains: A, B
Molecule details ›
Chains: A, B
Length: 348 amino acids
Theoretical weight: 39.44 KDa
Source organism: Pyrococcus furiosus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P81535 (Residues: 1-348; Coverage: 100%)
Gene names: PF1343, pepQ
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand ZN 4 x ZN
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: P21
Unit cell:
a: 56.476Å b: 97.227Å c: 69.882Å
α: 90° β: 97.09° γ: 90°
R-values:
R R work R free
0.246 0.245 0.277
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

8 review citations

Model organisms for genetics in the domain Archaea: methanogens, halophiles, Thermococcales and Sulfolobales.
Leigh et al. (2011)
7 more

11 mentions without citation

The FACT Spt16 "peptidase" domain is a histone H3-H4 binding module.
Stuwe et al. (2008)
10 more