› 1q7x

Solution NMR

Solution structure of the alternatively spliced PDZ2 domain (PDZ2b) of PTP-Bas (hPTP1E)

Released:
DOI: 10.2210/pdb1q7x/pdb
PDB entry 1q7x coloured by chain, ensemble of 20 models, front view.
PDB entry 1q7x coloured by chain, ensemble of 20 models, side view.
PDB entry 1q7x coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structure determination and ligand interactions of the PDZ2b domain of PTP-Bas (hPTP1E): splicing-induced modulation of ligand specificity.
Kachel N, Erdmann KS, Kremer W, Wolff P, Gronwald W, Heumann R, Kalbitzer HR
J Mol Biol 334 143-55 (2003)
PMID: 14596806

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171438 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein phosphatase non-receptor type 13 Chain: A
Molecule details ›
Chain: A
Length: 108 amino acids
Theoretical weight: 11.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q12923 (Residues: 1358-1383, 1384-1459; Coverage: 4%)
Gene names: PNP1, PTP1E, PTPL1, PTPN13
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

10 review citations

Protein tyrosine phosphatases: regulatory mechanisms.
den Hertog et al. (2008)
9 more

3 mentions without citation

Structure of PICK1 and other PDZ domains obtained with the help of self-binding C-terminal extensions.
Elkins et al. (2007)
2 more