› 1q8k

Solution NMR

Solution structure of alpha subunit of human eIF2

Released:
DOI: 10.2210/pdb1q8k/pdb
PDB entry 1q8k coloured by chain, ensemble of 15 models, front view.
PDB entry 1q8k coloured by chain, ensemble of 15 models, side view.
PDB entry 1q8k coloured by chain, ensemble of 15 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of human initiation factor eIF2alpha reveals homology to the elongation factor eEF1B.
Ito T, Marintchev A, Wagner G
Structure 12 1693-704 (2004)
PMID: 15341733

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138583 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Eukaryotic translation initiation factor 2 subunit 1 Chain: A
Molecule details ›
Chain: A
Length: 308 amino acids
Theoretical weight: 35.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05198 (Residues: 5-303; Coverage: 95%)
Gene names: EIF2A, EIF2S1
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Molecular mechanism of scanning and start codon selection in eukaryotes.
Hinnebusch AG. (2011)
6 more

8 mentions without citation

Structural and functional analysis of novel human cytochrome C targets in apoptosis.
Martínez-Fábregas et al. (2014)
7 more