› 1qdc

X-ray diffraction
2Å resolution

MAN(APLHA1-6)MAN(ALPHA1-O)METHYL CONCANAVALIN A COMPLEX

Released:
DOI: 10.2210/pdb1qdc/pdb
PDB entry 1qdc coloured by chain, front view.
PDB entry 1qdc coloured by chain, side view.
PDB entry 1qdc coloured by chain, top view.
Source organism: Canavalia ensiformis
Primary publication:
The crystal structures of Man(alpha1-3)Man(alpha1-O)Me and Man(alpha1-6)Man(alpha1-O)Me in complex with concanavalin A.
Bouckaert J, Hamelryck TW, Wyns L, Loris R
J Biol Chem 274 29188-95 (1999)
PMID: 10506175

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157353 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Concanavalin-Br Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 237 amino acids
Theoretical weight: 25.62 KDa
Source organism: Canavalia ensiformis
UniProt:
  • Canonical: P55915 (Residues: 1-237; Coverage: 100%)
Sequence domains: Legume lectin domain
Structure domains: Jelly Rolls

Ligands and Environments

Carbohydrate polymer : NEW Components: MMA, MAN
Carbohydrate polymer
3 bound ligands:
Ligand MN 4 x MN
Ligand CA 4 x CA
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P212121
Unit cell:
a: 69.51Å b: 117.03Å c: 120.92Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.175 0.175 0.211

Quick links

Citations

2 review citations

Proteins that bind high-mannose sugars of the HIV envelope.
Botos et al. (2005)
1 more

2 mentions without citation

Overview of the Structure⁻Function Relationships of Mannose-Specific Lectins from Plants, Algae and Fungi.
Barre et al. (2019)
1 more