› 1qe6

X-ray diffraction
2.35Å resolution

INTERLEUKIN-8 WITH AN ADDED DISULFIDE BETWEEN RESIDUES 5 AND 33 (L5C/H33C)

Released:
DOI: 10.2210/pdb1qe6/pdb
PDB entry 1qe6 coloured by chain, front view.
PDB entry 1qe6 coloured by chain, side view.
PDB entry 1qe6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Receptor-binding conformation of the "ELR" motif of IL-8: X-ray structure of the L5C/H33C variant at 2.35 A resolution.
Gerber N, Lowman H, Artis DR, Eigenbrot C
Proteins 38 361-7 (2000)
PMID: 10707023

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-145181 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interleukin-8 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 72 amino acids
Theoretical weight: 8.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P10145 (Residues: 28-99; Coverage: 91%)
Gene names: CXCL8, IL8
Sequence domains: Small cytokines (intecrine/chemokine), interleukin-8 like
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)

Ligands and Environments

1 bound ligand:
Ligand SO4 3 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: P21
Unit cell:
a: 37.54Å b: 71.77Å c: 57.86Å
α: 90° β: 90.46° γ: 90°
R-values:
R R work R free
0.211 0.208 0.278
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Functional aspects of the interaction between interleukin-8 and sulfated glycosaminoglycans.
Pichert et al. (2012)
10 other articles

4 mentions without citation

Novel drug candidates for treating esophageal carcinoma: A study on differentially expressed genes, using connectivity mapping and molecular docking.
Chen et al. (2019)
3 more