› 1qh4

X-ray diffraction
1.41Å resolution

CRYSTAL STRUCTURE OF CHICKEN BRAIN-TYPE CREATINE KINASE AT 1.41 ANGSTROM RESOLUTION

Released:
DOI: 10.2210/pdb1qh4/pdb
PDB entry 1qh4 coloured by chain, front view.
PDB entry 1qh4 coloured by chain, side view.
PDB entry 1qh4 coloured by chain, top view.
Source organism: Gallus gallus
Primary publication:
Crystal structure of brain-type creatine kinase at 1.41 A resolution.
Eder M, Schlattner U, Becker A, Wallimann T, Kabsch W, Fritz-Wolf K
Protein Sci 8 2258-69 (1999)
PMID: 10595529

Function and Biology Details

Reaction catalysed: 
ATP + creatine = ADP + phosphocreatine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-138533 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Creatine kinase B-type Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 380 amino acids
Theoretical weight: 42.8 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli
UniProt:
  • Canonical: P05122 (Residues: 2-381; Coverage: 100%)
Gene name: CKB
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand ACT 6 x ACT
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE BW7B
Spacegroup: P21
Unit cell:
a: 48.43Å b: 175.99Å c: 95.4Å
α: 90° β: 95.85° γ: 90°
R-values:
R R work R free
0.136 not available 0.188
Expression system: Escherichia coli

Quick links

Citations

5 review citations

The creatine kinase system and pleiotropic effects of creatine.
Wallimann et al. (2011)
4 more

13 mentions without citation

Mitochondrial dysfunction in mouse models of Parkinson's disease revealed by transcriptomics and proteomics.
Smith DJ. (2009)
12 more