› 1qk9

Solution NMR

The solution structure of the domain from MeCP2 that binds to methylated DNA

Released:
DOI: 10.2210/pdb1qk9/pdb
PDB entry 1qk9 coloured by chain, ensemble of 28 models, front view.
PDB entry 1qk9 coloured by chain, ensemble of 28 models, side view.
PDB entry 1qk9 coloured by chain, ensemble of 28 models, top view.
Source organism: Homo sapiens
Primary publication:
The solution structure of the domain from MeCP2 that binds to methylated DNA.
Wakefield RI, Smith BO, Nan X, Free A, Soteriou A, Uhrin D, Bird AP, Barlow PN
J Mol Biol 291 1055-65 (1999)
PMID: 10518942

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156374 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Methyl-CpG-binding protein 2 Chain: A
Molecule details ›
Chain: A
Length: 92 amino acids
Theoretical weight: 10.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P51608 (Residues: 77-168; Coverage: 19%)
Gene name: MECP2
Sequence domains: Methyl-CpG binding domain
Structure domains: Methyl-cpg-binding Protein 2; Chain A

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

43 review citations

DNA methylation in health and disease.
Robertson et al. (2000)
42 more

9 mentions without citation

Computational and experimental approaches to reveal the effects of single nucleotide polymorphisms with respect to disease diagnostics.
Kucukkal et al. (2014)
8 more