› 1qkm

X-ray diffraction
1.8Å resolution

HUMAN OESTROGEN RECEPTOR BETA LIGAND-BINDING DOMAIN IN COMPLEX WITH PARTIAL AGONIST GENISTEIN

Released:
DOI: 10.2210/pdb1qkm/pdb
PDB entry 1qkm coloured by chain, front view.
PDB entry 1qkm coloured by chain, side view.
PDB entry 1qkm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the ligand-binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonist.
Pike AC, Brzozowski AM, Hubbard RE, Bonn T, Thorsell AG, Engström O, Ljunggren J, Gustafsson JA, Carlquist M
EMBO J 18 4608-18 (1999)
PMID: 10469641

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187733 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Estrogen receptor beta Chain: A
Molecule details ›
Chain: A
Length: 255 amino acids
Theoretical weight: 28.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q92731 (Residues: 255-509; Coverage: 48%)
Gene names: ESR2, ESTRB, NR3A2
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand GEN 1 x GEN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P6122
Unit cell:
a: 63.12Å b: 63.12Å c: 250.23Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.215 0.215 0.252
Expression system: Escherichia coli

Quick links

Citations

138 review citations

Mechanisms of estrogen action.
Nilsson et al. (2001)
137 more

26 mentions without citation

Application of Various Molecular Modelling Methods in the Study of Estrogens and Xenoestrogens.
Mazurek et al. (2020)
25 more