› 1qlp

X-ray diffraction
2Å resolution

2.0 ANGSTROM STRUCTURE OF INTACT ALPHA-1-ANTITRYPSIN: A CANONICAL TEMPLATE FOR ACTIVE SERPINS

Released:
DOI: 10.2210/pdb1qlp/pdb
PDB entry 1qlp coloured by chain, front view.
PDB entry 1qlp coloured by chain, side view.
PDB entry 1qlp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Topography of a 2.0 A structure of alpha1-antitrypsin reveals targets for rational drug design to prevent conformational disease.
Elliott PR, Pei XY, Dafforn TR, Lomas DA
Protein Sci 9 1274-81 (2000)
PMID: 10933492

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133784 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-1-antitrypsin Chain: A
Molecule details ›
Chain: A
Length: 394 amino acids
Theoretical weight: 44.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P01009 (Residues: 26-418; Coverage: 100%)
Gene names: AAT, PI, PRO0684, PRO2209, SERPINA1
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX9.6
Spacegroup: C2
Unit cell:
a: 114.68Å b: 39.26Å c: 90.27Å
α: 90° β: 104.21° γ: 90°
R-values:
R R work R free
0.231 0.231 0.266
Expression system: Escherichia coli BL21(DE3)

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Citations

26 review citations

Cell-mediated immunity in arthropods: hematopoiesis, coagulation, melanization and opsonization.
Jiravanichpaisal et al. (2006)
25 more

80 mentions without citation

An overview of the serpin superfamily.
Law et al. (2006)
79 more