› 1qnk

Solution NMR

TRUNCATED HUMAN GROB[5-73], NMR, 20 STRUCTURES

Released:
DOI: 10.2210/pdb1qnk/pdb
PDB entry 1qnk coloured by chain, ensemble of 20 models, front view.
PDB entry 1qnk coloured by chain, ensemble of 20 models, side view.
PDB entry 1qnk coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Nuclear magnetic resonance solution structure of truncated human GRObeta [5-73] and its structural comparison with CXC chemokine family members GROalpha and IL-8.
Qian YQ, Johanson KO, McDevitt P
J Mol Biol 294 1065-72 (1999)
PMID: 10600366

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148777 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
C-X-C motif chemokine 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 69 amino acids
Theoretical weight: 7.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P19875 (Residues: 39-107; Coverage: 95%)
Gene names: CXCL2, GRO2, GROB, MIP2A, SCYB2
Sequence domains: Small cytokines (intecrine/chemokine), interleukin-8 like
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Structure, function, and inhibition of chemokines.
Fernandez et al. (2002)
4 more

8 mentions without citation

The marriage of chemokines and galectins as functional heterodimers.
von Hundelshausen et al. (2021)
7 more