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STRUCTURAL ANALYSIS OF THE LYMPHOCYTE-SPECIFIC KINASE LCK IN COMPLEX WITH NON-SELECTIVE AND SRC FAMILY SELECTIVE KINASE INHIBITORS

X-ray diffraction
1.6Å resolution
PDB entry 1qpc coloured by chain, front view.
PDB entry 1qpc coloured by chain, side view.
PDB entry 1qpc coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Tyrosine-protein kinase Lck
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Multimeric state: monomeric
PDBe Complex ID: PDB-CPX-138948

Macromolecules

Tyrosine-protein kinase Lck
Chain: A
Length: 279 amino acids
Theoretical weight: 32.35 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P06239 (Residues: 231-509; Coverage: 55%)
Gene name: LCK
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
CATH:
SCOP: Protein kinases, catalytic subunit
Tyrosine-protein kinase Lck in PDB entry 1qpc, assembly 1, front view.
Tyrosine-protein kinase Lck in PDB entry 1qpc, assembly 1, side view.
Tyrosine-protein kinase Lck in PDB entry 1qpc, assembly 1, top view.
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