› 1qpf

X-ray diffraction
2.5Å resolution

FK506 BINDING PROTEIN (12 KDA, HUMAN) COMPLEX WITH L-709,858

Released:
DOI: 10.2210/pdb1qpf/pdb
PDB entry 1qpf coloured by chain, front view.
PDB entry 1qpf coloured by chain, side view.
PDB entry 1qpf coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
32-Indolyl ether derivatives of ascomycin: three-dimensional structures of complexes with FK506-binding protein.
Becker JW, Rotonda J, Cryan JG, Martin M, Parsons WH, Sinclair PJ, Wiederrecht G, Wong F
J Med Chem 42 2798-804 (1999)
PMID: 10425089

Function and Biology Details

Reaction catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-158814 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidyl-prolyl cis-trans isomerase FKBP1A Chains: A, D
Molecule details ›
Chains: A, D
Length: 107 amino acids
Theoretical weight: 11.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P62942 (Residues: 2-108; Coverage: 99%)
Gene names: FKBP1, FKBP12, FKBP1A
Sequence domains: FKBP-type peptidyl-prolyl cis-trans isomerase
Structure domains: Chitinase A; domain 3

Ligands and Environments

2 bound ligands:
Ligand 858 2 x 858
Ligand B7G 1 x B7G
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P6122
Unit cell:
a: 74.26Å b: 74.26Å c: 236.45Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.243 0.243 0.31
Expression system: Escherichia coli

Quick links

Citations

7 citation in other articles

Role for A kinase-anchoring proteins (AKAPS) in glutamate receptor trafficking and long term synaptic depression.
Snyder et al. (2005)
6 more