› 1quu

X-ray diffraction
2.5Å resolution

CRYSTAL STRUCTURE OF TWO CENTRAL SPECTRIN-LIKE REPEATS FROM ALPHA-ACTININ

Released:
DOI: 10.2210/pdb1quu/pdb
PDB entry 1quu coloured by chain, front view.
PDB entry 1quu coloured by chain, side view.
PDB entry 1quu coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the alpha-actinin rod: molecular basis for cross-linking of actin filaments.
Djinović-Carugo K, Young P, Gautel M, Saraste M
Cell 98 537-46 (1999)
PMID: 10481917

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152961 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-actinin-2 Chain: A
Molecule details ›
Chain: A
Length: 250 amino acids
Theoretical weight: 29.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35609 (Residues: 391-637; Coverage: 28%)
Gene name: ACTN2
Sequence domains: Spectrin repeat
Structure domains: Methane Monooxygenase Hydroxylase; Chain G, domain 1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-3
Spacegroup: P6522
Unit cell:
a: 60.05Å b: 60.05Å c: 390.81Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.228 0.228 0.31
Expression system: Escherichia coli

Quick links

Citations

27 review citations

Spectrin and ankyrin-based pathways: metazoan inventions for integrating cells into tissues.
Bennett et al. (2001)
26 more

10 mentions without citation

Dystrophins and dystrobrevins.
Roberts RG. (2001)
9 more