› 1qy1

X-ray diffraction
1.7Å resolution

Thermodynamics of Binding of 2-methoxy-3-isopropylpyrazine and 2-methoxy-3-isobutylpyrazine to the Major Urinary Protein

Released:
DOI: 10.2210/pdb1qy1/pdb
PDB entry 1qy1 coloured by chain, front view.
PDB entry 1qy1 coloured by chain, side view.
PDB entry 1qy1 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Thermodynamics of binding of 2-methoxy-3-isopropylpyrazine and 2-methoxy-3-isobutylpyrazine to the major urinary protein.
Bingham RJ, Findlay JB, Hsieh SY, Kalverda AP, Kjellberg A, Perazzolo C, Phillips SE, Seshadri K, Trinh CH, Turnbull WB, Bodenhausen G, Homans SW
J Am Chem Soc 126 1675-81 (2004)
PMID: 14871097

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-145879 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Major urinary protein 1 Chain: A
Molecule details ›
Chain: A
Length: 174 amino acids
Theoretical weight: 20.14 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P11588 (Residues: 17-180; Coverage: 100%)
Gene name: Mup1
Sequence domains: Lipocalin / cytosolic fatty-acid binding protein family
Structure domains: Lipocalin

Ligands and Environments

3 bound ligands:
Ligand CD 2 x CD
Ligand NA 4 x NA
Ligand PRZ 1 x PRZ
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: P43212
Unit cell:
a: 53.575Å b: 53.575Å c: 137.562Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.183 0.181 0.21
Expression system: Escherichia coli

Quick links

Citations

13 review citations

Scent wars: the chemobiology of competitive signalling in mice.
Hurst et al. (2004)
12 more

5 mentions without citation

Characterization of the fast dynamics of protein amino acid side chains using NMR relaxation in solution.
Igumenova et al. (2006)
4 more