› 1qz2

X-ray diffraction
3Å resolution

Crystal Structure of FKBP52 C-terminal Domain complex with the C-terminal peptide MEEVD of Hsp90

Released:
DOI: 10.2210/pdb1qz2/pdb
PDB entry 1qz2 coloured by chain, front view.
PDB entry 1qz2 coloured by chain, side view.
PDB entry 1qz2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
3D structure of human FK506-binding protein 52: implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilin heterocomplex.
Wu B, Li P, Liu Y, Lou Z, Ding Y, Shu C, Ye S, Bartlam M, Shen B, Rao Z
Proc Natl Acad Sci U S A 101 8348-53 (2004)
PMID: 15159550

Function and Biology Details

Reaction catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140054 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 336 amino acids
Theoretical weight: 38.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q02790 (Residues: 145-459; Coverage: 69%)
Gene names: FKBP4, FKBP52
Sequence domains:
Structure domains:
Heat shock protein HSP 90-beta Chains: G, H
Molecule details ›
Chains: G, H
Length: 5 amino acids
Theoretical weight: 622 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P08238 (Residues: 720-724; Coverage: 1%)
Gene names: HSP90AB1, HSP90B, HSPC2, HSPC3, HSPCB

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: C2221
Unit cell:
a: 111.613Å b: 144.417Å c: 170.815Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.235 0.23 0.287
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

24 review citations

How corticosteroids control inflammation: Quintiles Prize Lecture 2005.
Barnes PJ. (2006)
23 more

11 mentions without citation

Structure and function of SET and MYND domain-containing proteins.
Spellmon et al. (2015)
10 more