› 1r02

Solution NMR

Solution structure of Human Orexin-A:Regulator of Appetite and Wakefulness

Released:
DOI: 10.2210/pdb1r02/pdb
PDB entry 1r02 coloured by chain, front view.
PDB entry 1r02 coloured by chain, side view.
PDB entry 1r02 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of human orexin-A: regulator of appetite and wakefulness.
Kim HY, Hong E, Kim JI, Lee W
J Biochem Mol Biol 37 565-73 (2004)
PMID: 15479620

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129028 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Orexin-A Chain: A
Molecule details ›
Chain: A
Length: 33 amino acids
Theoretical weight: 3.59 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: O43612 (Residues: 34-66; Coverage: 34%)
Gene names: HCRT, OX, PPORX, PPOX

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry, simulated annealing, molecular dynamics
Expression system: Not provided

Quick links

Citations

7 review citations

Orexin neuronal circuitry: role in the regulation of sleep and wakefulness.
Ohno et al. (2008)
6 more

1 mention without citation

An in silico scientific basis for LL-37 as a therapeutic for Covid-19.
Lokhande et al. (2022)