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Structural Basis for Differential Recognition of Tyrosine Phosphorylated Sites in the Linker for Activation of T cells (LAT) by the Adaptor Protein Gads

X-ray diffraction
1.8Å resolution
PDB entry 1r1q coloured by chain, front view.
PDB entry 1r1q coloured by chain, side view.
PDB entry 1r1q coloured by chain, top view.
Source organism: Mus musculus
Assemblies composition:
hetero dimer (preferred)
hetero tetramer
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: GRB2-related adaptor protein 2 and peptide
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Multimeric state: hetero dimer
Accessible surface area: 6283.36 Å2
Buried surface area: 1359.16 Å2
Dissociation area: 517.99 Å2
Dissociation energy (ΔGdiss): 8.41 kcal/mol
Dissociation entropy (TΔSdiss): 6.6 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-131609
Assembly 2
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Assembly Name: GRB2-related adaptor protein 2 and peptide
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Multimeric state: hetero dimer
Accessible surface area: 6473.21 Å2
Buried surface area: 1607.47 Å2
Dissociation area: 495.61 Å2
Dissociation energy (ΔGdiss): 9.83 kcal/mol
Dissociation entropy (TΔSdiss): 6.66 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-131609
Assembly 3
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Assembly Name: GRB2-related adaptor protein 2 and peptide
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Multimeric state: hetero tetramer
Accessible surface area: 10564.04 Å2
Buried surface area: 5163.17 Å2
Dissociation area: 1,089.62 Å2
Dissociation energy (ΔGdiss): 16.69 kcal/mol
Dissociation entropy (TΔSdiss): 11.01 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-131614

Macromolecules

GRB2-related adaptor protein 2
Chains: A, B
Length: 100 amino acids
Theoretical weight: 11.82 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: O89100 (Residues: 50-147; Coverage: 30%)
Gene names: Gads, Grap2, Grb2l, Grid, Mona
Pfam: SH2 domain
InterPro:
CATH: SH2 domain
SCOP: SH2 domain
GRB2-related adaptor protein 2 in PDB entry 1r1q, assembly 1, front view.
GRB2-related adaptor protein 2 in PDB entry 1r1q, assembly 1, side view.
GRB2-related adaptor protein 2 in PDB entry 1r1q, assembly 1, top view.
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LAT pY191 peptide
Chains: C, D
Length: 7 amino acids
Theoretical weight: 886 Da
Source organism: Mus musculus
Expression system: Not provided
LAT pY191 peptide in PDB entry 1r1q, assembly 1, front view.
LAT pY191 peptide in PDB entry 1r1q, assembly 1, side view.
LAT pY191 peptide in PDB entry 1r1q, assembly 1, top view.
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