› 1ral

X-ray diffraction
3Å resolution

THREE-DIMENSIONAL STRUCTURE OF RAT LIVER 3ALPHA-HYDROXYSTEROID(SLASH)DIHYDRODIOL DEHYDROGENASE: A MEMBER OF THE ALDO-KETO REDUCTASE SUPERFAMILY

Released:
DOI: 10.2210/pdb1ral/pdb
PDB entry 1ral coloured by chain, front view.
PDB entry 1ral coloured by chain, side view.
PDB entry 1ral coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Three-dimensional structure of rat liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase: a member of the aldo-keto reductase superfamily.
Hoog SS, Pawlowski JE, Alzari PM, Penning TM, Lewis M
Proc Natl Acad Sci U S A 91 2517-21 (1994)
PMID: 8146147

Function and Biology Details

Reaction catalysed: 
A 3-alpha-hydroxysteroid + NAD(P)(+) = a 3-oxosteroid + NAD(P)H
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149966 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
3-alpha-hydroxysteroid dehydrogenase Chain: A
Molecule details ›
Chain: A
Length: 308 amino acids
Theoretical weight: 35.33 KDa
Source organism: Rattus norvegicus
Expression system: Not provided
UniProt:
  • Canonical: P23457 (Residues: 1-308; Coverage: 96%)
Gene name: Akr1c9
Sequence domains: Aldo/keto reductase family
Structure domains: NADP-dependent oxidoreductase domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: C2221
Unit cell:
a: 51.3Å b: 89.5Å c: 143.3Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.22 0.22 not available
Expression system: Not provided

Quick links

Citations

18 review citations

The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders.
Miller et al. (2011)
17 more

2 mentions without citation

The skeletal muscle Ca2+ release channel has an oxidoreductase-like domain.
Baker et al. (2002)
1 more