› 1rfx

X-ray diffraction
2Å resolution

Crystal Structure of resisitin

Released:
DOI: 10.2210/pdb1rfx/pdb
PDB entry 1rfx coloured by chain, front view.
PDB entry 1rfx coloured by chain, side view.
PDB entry 1rfx coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Disulfide-dependent multimeric assembly of resistin family hormones.
Patel SD, Rajala MW, Rossetti L, Scherer PE, Shapiro L
Science 304 1154-8 (2004)
PMID: 15155948

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
homo trimer (preferred)
homo hexamer
Assembly name:
PDBe Complex ID:
PDB-CPX-189372 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Resistin Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 94 amino acids
Theoretical weight: 10.18 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q99P87 (Residues: 21-114; Coverage: 100%)
Gene names: Fizz3, Retn
Sequence domains: Resistin
Structure domains:

Ligands and Environments

4 bound ligands:
Ligand CL 11 x CL
Ligand ACT 7 x ACT
Ligand PGE 1 x PGE
Ligand PEG 1 x PEG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: C2221
Unit cell:
a: 44.298Å b: 174.67Å c: 90.163Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.179 0.177 0.216
Expression system: Homo sapiens

Quick links

Citations

69 review citations

Adipokines in inflammation and metabolic disease.
Ouchi et al. (2011)
68 more

4 mentions without citation

Resistin, a Novel Host Defense Peptide of Innate Immunity.
Li et al. (2021)
3 more