› 1rgd

Solution NMR

STRUCTURE REFINEMENT OF THE GLUCOCORTICOID RECEPTOR-DNA BINDING DOMAIN FROM NMR DATA BY RELAXATION MATRIX CALCULATIONS

Released:
DOI: 10.2210/pdb1rgd/pdb
PDB entry 1rgd coloured by chain, ensemble of 11 models, front view.
PDB entry 1rgd coloured by chain, ensemble of 11 models, side view.
PDB entry 1rgd coloured by chain, ensemble of 11 models, top view.
Source organism: Rattus norvegicus
Primary publication:
Structure refinement of the glucocorticoid receptor-DNA binding domain from NMR data by relaxation matrix calculations.
van Tilborg MA, Bonvin AM, Hård K, Davis AL, Maler B, Boelens R, Yamamoto KR, Kaptein R
J Mol Biol 247 689-700 (1995)
PMID: 7723024

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139078 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glucocorticoid receptor Chain: A
Molecule details ›
Chain: A
Length: 71 amino acids
Theoretical weight: 7.96 KDa
Source organism: Rattus norvegicus
Expression system: Not provided
UniProt:
  • Canonical: P06536 (Residues: 440-510; Coverage: 9%)
Gene names: Grl, Nr3c1
Sequence domains: Zinc finger, C4 type (two domains)
Structure domains: Erythroid Transcription Factor GATA-1, subunit A

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Expression system: Not provided

Quick links

Citations

5 review citations

Allosteric effects of DNA on transcriptional regulators.
Lefstin et al. (1998)
4 more

3 mentions without citation

Ensemble allosteric model: energetic frustration within the intrinsically disordered glucocorticoid receptor.
White et al. (2018)
2 more