› 1rgs

X-ray diffraction
2.8Å resolution

REGULATORY SUBUNIT OF CAMP DEPENDENT PROTEIN KINASE

Released:
DOI: 10.2210/pdb1rgs/pdb
PDB entry 1rgs coloured by chain, front view.
PDB entry 1rgs coloured by chain, side view.
PDB entry 1rgs coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Regulatory subunit of protein kinase A: structure of deletion mutant with cAMP binding domains.
Su Y, Dostmann WR, Herberg FW, Durick K, Xuong NH, Ten Eyck L, Taylor SS, Varughese KI
Science 269 807-13 (1995)
PMID: 7638597

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132578 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed Chain: A
Molecule details ›
Chain: A
Length: 288 amino acids
Theoretical weight: 32.49 KDa
Source organism: Bos taurus
Expression system: Escherichia coli
UniProt:
  • Canonical: P00514 (Residues: 93-380; Coverage: 76%)
Gene name: PRKAR1A
Sequence domains: Cyclic nucleotide-binding domain
Structure domains: Jelly Rolls

Ligands and Environments

1 bound ligand:
Ligand CMP 2 x CMP
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P6522
Unit cell:
a: 88.9Å b: 88.9Å c: 179.9Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.217 0.217 not available
Expression system: Escherichia coli

Quick links

Citations

45 review citations

Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm.
Newton AC. (2003)
44 more

59 mentions without citation

Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development.
Robichaux et al. (2018)
58 more