› 1rhf

X-ray diffraction
1.96Å resolution

Crystal Structure of human Tyro3-D1D2

Released:
DOI: 10.2210/pdb1rhf/pdb
PDB entry 1rhf coloured by chain, front view.
PDB entry 1rhf coloured by chain, side view.
PDB entry 1rhf coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Ligand recognition and homophilic interactions in Tyro3: structural insights into the Axl/Tyro3 receptor tyrosine kinase family.
Heiring C, Dahlbäck B, Muller YA
J Biol Chem 279 6952-8 (2004)
PMID: 14623883

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170340 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase receptor TYRO3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 182 amino acids
Theoretical weight: 19.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q06418 (Residues: 41-222; Coverage: 21%)
Gene names: BYK, DTK, RSE, SKY, TIF, TYRO3
Sequence domains: Immunoglobulin I-set domain
Structure domains: Immunoglobulins

Ligands and Environments

3 bound ligands:
Ligand ZN 1 x ZN
Ligand ACT 4 x ACT
Ligand EPE 1 x EPE
1 modified residue:
Ligand MSE 4 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P61
Unit cell:
a: 109.55Å b: 109.55Å c: 62.47Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.213 0.209 0.256
Expression system: Escherichia coli

Quick links

Citations

22 review citations

TAM receptor tyrosine kinases: biologic functions, signaling, and potential therapeutic targeting in human cancer.
Linger et al. (2008)
21 more

5 mentions without citation

The self-inhibited structure of full-length PCSK9 at 1.9 A reveals structural homology with resistin within the C-terminal domain.
Hampton et al. (2007)
4 more